Pepper (Capsicum frutescens L.) and summer squash (Cucurbita pepo var. melopepo (L.) Alef.) were grown in immediate succession in undisturbed beds using trickle irrigation with various treatments. Highest combined yield in metric tons/ha for both crops was obtained with film mulch + soil fumigation (117.6) followed by film mulch (112.3), soil fumigation (93.4) and control (69.0), respectively. Yield from the second crop was negatively correlated (r=−.87) with the degree of plant infection with root-knot nematode (Meloidogyne incognita (Kofoid & White) Chitwood). Intensive production in this manner allows fixed costs to be defrayed over two crops thus increasing the magnitude of return per dollar invested. Multiple cropping of pepper and squash with trickle irrigation has an excellent potential in south Georgia provided nematodes and other soil-borne pathogens can be adequately controlled.