This paper describes the field research and development (FRD) process followed by agrochemical companies when developing a new plant growth regulator (PGR). Specific approaches used by Valent BioSciences Corporation in developing EcoLyst, a newly registered PGR for use on orange (Citrus sinensis) in the United States, are cited as examples of this process. Agrochemical companies acquire some new PGR compounds from outside sources, while others are discovered internally. Internal development of new compounds is simpler to control and manage. When a new PGR is identified from an outside source, a company must first determine if the compound is available for licensing or outright purchase. If so, they assemble a team of internal experts to review all available data (due diligence) to determine if it has sufficient value to warrant pursuit. Once a PGR passes the initial screening processes and is approved for acquisition and potential development, negotiations begin with the owner of the compound. Many projects stop abruptly when the negotiating companies fail to reach an agreement. Immediately after an agrochemical company successfully acquires a new PGR, a well-coordinated chain of events is initiated throughout the company's organization to accelerate work on the project. One component of this involves the FRD team, which creates a comprehensive field research plan for the PGR containing clearly defined development goals that are global in scope. The FRD team works throughout the world, near important crop production areas, conducting research with the company's products. Members of the FRD team generally report to a research leader located at the company's main headquarters. The FRD team is one part of a larger development team, that works collectively to find and develop promising new compounds and new uses for existing company products. If initial research results from a new compound are favorable, the objectives of the workplan increase significantly after the first year. University and government researchers are generally brought into the research programs after a year or two of in-house testing. Early stage work is often done under a secrecy agreement in order to protect proprietary information and interests. Specific control points are identified in the development process, where decisions are made to continue or not, based on reviews of research data, business plans, and regulatory progress.
Alan W. Meerow, Sven E. Svenson and Michael E. Kane
DCPTA is a synthetically produced tertiary amine bioregulator with potential for increasing crop productivity at high light intensities. DCPTA reduces the number of days from planting to maturity in various potted ornamental crops, including `Fortune' daffodil (Narcissus L.), `Sonora' tulip (Tulipa L.), and `Jan Bos' hyacinth (Hyacinthus orientalis L.). Our objective was to examine how light intensity and DCPTA application influence growth and flowering of amaryllis (Hippeastrum hybridum Hort.). Flowering size bulbs of a micropropagated amaryllis clone were treated with 30 μm or no DCPTA and grown in full sun or 63% shade for 1 year. Number of scapes produced, flowers per scape, change in bulb fresh weight, number of bulblets produced, and bulblet weight were recorded and analyzed. There were no significant differences in days to first flowering or in number of flowers produced per scape among the treatments. DCPTA application at the recommended rate significantly reduced number of emergent inflorescences and the bulb biomass increase of hybrid amaryllis. Additionally, the interaction between light level and DCPTA appeared weak for amaryllis, and was only slightly significant relative to bulblet production. Chemical name used: 2-(3,4-dichlorophenoxy)triethylamine (DCPTA).
Steven F. Vaughn, Mark A. Berhow and Brent Tisserat
greenhouse-grown tomato (Lycopersicon esculentum Mill.) seedlings ( Latimer, 1992 ). The synthetic tertiary amine DCPTA [2-(3,4-dichlorophenoxy)triethylamine] was found to promote growth and initiate flowering in Phalaenopsis orchids and heliconias (Heliconia