‘Lapins’ sweet cherry (Prunus avium L.) on Gisela 5 (Prunus cerasus × Prunus canescens) rootstock were subjected to a factorial combination of two crop load and eight fertigation treatments from the sixth to the eight growing seasons. Crop load treatments included full crop and dormant spur thinning to remove and maintain 50% of fruiting spurs. The eight fertigation treatments, which had been maintained since the first growing season, included low (42 mg·L−1), medium (84 mg·L−1), and high (168 mg·L−1) concentrations of N applied by sprinkler fertigation of Ca(NO3)2 annually ≈8 weeks postbloom. The medium N concentration was also applied with P fertigated in early spring or K fertigated in June. A standard N treatment involved broadcast application of NH4NO3 in early spring at 75 kg·ha−1 also followed with medium N sprinkler-fertigated postharvest in August. The medium N concentration was also supplied for 8 weeks postbloom through drip emitters. Removal of 50% of fruiting spurs decreased annual yield on average by only 10%. Average fruit size could be increased in years of high crop load (greater than 400 g fruit/cm2 trunk cross-sectional area), but in a year of low crop load (less than 100 g fruit/cm2), fruit size was very large (averaging greater than 14 g) and unaffected by crop load adjustment. Minimal effects on fruit and leaf NPK concentrations, fruit firmness, soluble solids concentration (SSC), and titratable acidity (TA) were associated with yield reductions of 10%. Fertigation treatments resulted in a large range in tree vigor and yield during the experiment. High N applications reduced tree and fruit size and fruit TA and were undesirable. Annual P and K fertigation by sprinklers was generally ineffective, having minimal effects on tree PK nutrition and fruit quality with the exception of increased fruit firmness associated with P fertigation in 2005, when yield was low. Drip-fertigated trees were small, frequently had fruit with elevated SSC, but had deficient leaf K concentrations in 2004 implying a need to fertigate K when drip-irrigating.