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Yuko Yoshizawa, Kenji Sakurai, Satoru Kawaii, Masayoshi Asari, Junichi Soejima, and Noboru Murofushi

Aqueous ethanol extracts prepared from 19 apple (Malus ×domestica Borkh.) cultivars were studied to explore their antiproliferative activity. Half of them showed strong inhibition on proliferation of human leukemic HL-60 cells, while the others were weak. Total polyphenols, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and total anthocyanins were measured and the results indicated that the antiproliferative activity was more strongly correlated to the polyphenols and radical scavenging activity than to the anthocyanin content. Several polyphenols in `Jonathan' were identified and quantified by high-performance liquid chromatography (HPLC) analysis. Among those compounds found during HPLC, catechin and epicatechin seemed partially responsible for HL-60 antiproliferation. A careful examination on parentage of the apple cultivars tested revealed that `Jonathan' and its progeny showed high antiproliferation toward HL-60. This is the first observation about the relationship between antiproliferative activity and parentage of apples, and the information would be useful to create new apple cultivars that posses more anticancer potential.

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Shiow Wang, Kimberly Lewers, Linda Bowman, and Min Ding

Representatives of three species of strawberries (Fragaria virginiana, F. chiloensis and F. ×ananassa) were evaluated for antioxidant capacity, scavenging capacity for reactive oxygen species (ROO·, ·OH, 1O2 and O2 .-), and inhibitory effect on proliferation of A549 human lung epithelial cancer cells. Differences among the strawberry genotypes were observed for all three qualities. High antioxidant and scavenging capacities were found in `CFRA 0982', `JP 95-1-1', NC 95-19-1 and RH 30. Lowest antioxidant and scavenging capacities were found in `Allstar'. There was also a relationship between scavenging capacity and the inhibition of cancer cell proliferation. The correlations (R 2) between the scavenging capacities for the reactive oxygen species and the inhibition of cancer cell proliferation were 0.8074, 0.8279, 0.7862 and 0.7761 for ROO·, ·OH, 1O2 and O2 .-, respectively. These results suggest that antioxidants, specifically their scavenging capacities, may play an important role in the antiproliferative activity of strawberries. This study also identified strawberry germplasm of value in developing cultivars useful for cancer prevention.

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Shiow Y. Wang, Kim S. Lewers, Linda Bowman, and Min Ding

in the comparison, fruit extracts of F. × ananassa were significantly lower in SOD, GSH-POD, MDAR, and GR activities. Inhibition of proliferation of cancer cells. Antiproliferative activities of different genotypes of strawberry fruit

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Yi-Lun Liao, Wen-Shin Lin, and Shu-Yun Chen

control. In addition, job’s tears cultivar Thai Black Loei, which has antiproliferative activity and apoptosis, has been shown to be a potential medicine to treat cancer ( Manosroi et al., 2016 ). In Taiwan, the ecological traits of job’s tears are an area

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Ah-Chiou Lee, Fang-Shin Liao, and Hsiao-Feng Lo

, M.P. Liu, R.H. 2003 Antioxidant and antiproliferative activities of strawberries J. Agr. Food Chem. 51 6887 6892 Nagata, R.T. 1992 Clip-and-wash method of emasculation for lettuce HortScience 27 907 908 Nicolle, C. Carnat, A. Fraisse, D. Lamaison, J

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John Bamberg and Alfonso del Rio

phenolic content in potato germplasm Amer. J. Potato Res. 84 323 330 Nzaramba, Ndambe, M. Reddivari, L. Bamberg, J.B. Miller, J.C. Jr 2009 Antiproliferative activity and cytotoxicity of Solanum jamesii tuber extracts on human colon and prostate cancer

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Hideka Kobayashi, Changzheng Wang, and Kirk W. Pomper

144 153 Sun, J. Chu, Y.-F. Wu, X. Liu, R.H. 2002 Antioxidant and antiproliferative activities of common fruits J. Agr. Food Chem. 50 7449 7454 Taruscio, T.G. Barney, D

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Malkeet S. Padda and D.H. Picha

.J. Lin, Y.H. 2004 Antioxidant and antiproliferative activities of sweet potato [ Ipomoea batatas (L.) Lam ‘Tainong 57’] constituents Bot. Bul. Academia Sinica 45 179 186 Islam, S. 2006 Sweetpotato ( Ipomoea

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Brenner L. Freeman, Janet C. Stocks, Dennis L. Eggett, and Tory L. Parker

. Lee, C.Y. Brown, J. Liu, R.H. 2002 Antioxidant and antiproliferative activities of raspberries J. Agr. Food Chem. 50 2926 2930 Mazza, G. Miniati, E. 1993 Anthocyanins in fruits vegetables and grains CRC Press Boca Raton, FL 105 Ozgen, M. Wyzgoskiz, F

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Claudia A. Espinosa-Leal and Silverio Garcia-Lara

towards efficient production of its valuable leaf extracts showing antiproliferative activity on murine myeloma cells Plant Biosyst. 143 233 240 Cardarelli, M. Rouphael, Y. Pellizzoni, M. Colla, G. Lucini, L. 2017 Profile of bioactive secondary metabolites