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Yuko Yoshizawa, Kenji Sakurai, Satoru Kawaii, Masayoshi Asari, Junichi Soejima, and Noboru Murofushi

Aqueous ethanol extracts prepared from 19 apple (Malus ×domestica Borkh.) cultivars were studied to explore their antiproliferative activity. Half of them showed strong inhibition on proliferation of human leukemic HL-60 cells, while the others were weak. Total polyphenols, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and total anthocyanins were measured and the results indicated that the antiproliferative activity was more strongly correlated to the polyphenols and radical scavenging activity than to the anthocyanin content. Several polyphenols in `Jonathan' were identified and quantified by high-performance liquid chromatography (HPLC) analysis. Among those compounds found during HPLC, catechin and epicatechin seemed partially responsible for HL-60 antiproliferation. A careful examination on parentage of the apple cultivars tested revealed that `Jonathan' and its progeny showed high antiproliferation toward HL-60. This is the first observation about the relationship between antiproliferative activity and parentage of apples, and the information would be useful to create new apple cultivars that posses more anticancer potential.

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Shiow Wang, Ren-tian Feng, Linda Bowman, Ross Penhallegon, and Min Ding

The effects of lingonberry (Vaccinium vitis-idaea L.) extracts on activator protein-1 (AP-1), nuclear factor-kappaB (NF-κB), and mitogen-activated protein kinases (MAPKs) were evaluated. Pretreatment of JB6 P+ mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition of AP-1 and NF-κB induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB) light. Lingonberry extracts blocked UVB-induced phosphorylation of MAPK family members ERK1, ERK2, and p38, but not JNK. Lingonberry extracts also prevented TPA-induced phosphorylation of ERK1 and ERK2. Results of soft agar assays indicated that lingonberry extracts suppressed TPA-induced neoplastic transformation of JB6 P+

cells in a dose-dependent manner. Lingonberry extracts also induced the apoptosis of human leukemia HL-60 cells in a dose-independent manner. These results suggest that ERK1 and ERK2 may be inhibited by lingonberries, which results in suppression of AP-1 and neoplastic transformation in JB6 P+ cells and causes cancer cell death by an apoptotic mechanism in human leukemia HL-60 cells.

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Todd C. Wehner, Rachel P. Naegele, and Penelope Perkins-Veazie

438 442 Amir, H. Karas, M. Giat, J. Danilenko, M. Levy, R. Yermiahu, T. Levi, J. Sharoni, Y. 1999 Lycopene and 1, 25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells Nutr

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Juanxu Liu, Min Deng, Richard J. Henny, Jianjun Chen, and Jiahua Xie

. Sashida, Y. 1999 Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells Phytochemistry 50 805 813 Mimaki, Y. Kuroda, M. Takaashi, Y. Sashida, Y

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Yaser Hassan Dewir, Abdulhakim A. Aldubai, Rashid Sultan Al-Obeed, Salah El-Hendawy, Mayada Kadri Seliem, and Khadija Rabeh Al-Harbi

plants In Vitro 12 797 813 Mimaki, Y. Kuroda, M. Ido, A. Kameyama, A. Yokusuka, A. Sashida, Y. 1999 Steroidal saponin from the aerial parts of Dracaena draco and their cytostatic activity on HL 60 cells Phytochemistry 50 805 813 Mohamed-Yasseen, Y. 2002

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M. Joseph Stephens, Jessica Scalzo, Peter A. Alspach, Ron A. Beatson, and Ann Marie Connor

, M. 2006 Effects of anthocyanins and other phenolics of boysenberry and blackcurrant as inhibitors of oxidative stress and damage to cellular DNA in SH-SY5Y and HL-60 cells J. Sci. Food Agr. 86 678 686 Gilmour, A

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Jordan L. Hartman, Penelope Perkins-Veazie, and Todd C. Wehner

inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells Nutr. Cancer 33 105 112 Arab, L. Steck, S. 2000 Lycopene and cardiovascular disease Amer. J. Clin. Nutr. 71 1691S 1695S Ashraf, M. Harris, P.J. 2004 Potential