Gesnariad (Primulina yungfuensis) is a popular houseplant species, native to southwest China. However, stunting frequently occurs as a result of limited knowledge about the growth requirements of this plant. Understanding water and fertilizer requirements of gesnariad are important for effective large-scale greenhouse cultivation. Using a response surface methodology (RSM) based on a rotatable central composite design (RCCD; half implementation), a pot experiment was performed in a natural-light greenhouse from June to Sept. 2014. The study assessed the interaction between irrigation volume (W) and nitrogen (N), phosphorus (P), and potassium (K) fertilizer rates on plant height, crown diameter, number of leaves, single leaf area, and fresh weight. Results showed that W had a significant positive effect on plant height, crown diameter, single leaf area, and fresh weight. Furthermore, P fertilization resulted in increased leaf number. Combined P and K fertilization reduced individual leaf area, whereas combined N and P fertilization reduced fresh weight. By analyzing the multiobjective decision-making model, we found that a combination of 100.2 mL water, 3.6 mmol·L−1 N, 0.10 mmol·L−1 P, and 1.2 mmol·L−1 K could be used to achieve optimum growth of gesnariad.