The use of dicamba and 2,4-D products on herbicide-tolerant crops has resulted in numerous cases of off-target movement and injury to sensitive plants, including tomato (Solanum lycopersicon L.). Two greenhouse studies were conducted to determine whether ‘Big Beef’ (‘BB’) or ‘Florida 91’ (‘FL’) tomato plants pretreated with an antitranspirant, including Moisture-Loc (ML) at 100 mL·L−1, TransFilm (TF) at 50 g·L−1, or Wilt-Pruf (WP) at 100 mL·L−1, mitigated injury from synthetic auxin herbicides. Dicamba or 2,4-D was applied at a rate corresponding to 1/200 of the manufacturer’s labeled rate of 0.56 kg ae/ha or 1.06 kg ae/ha, respectively. At 2 weeks after treatment (WAT), plants treated with ML or WP before either herbicide exhibited injury symptoms, but they were always less severe than those treated with the herbicide alone for both cultivars. However, shoot length measurements indicated that none of the antitranspirants consistently provided protection against herbicide injury at 2 WAT. By 12 WAT, ML or WP used before either herbicide increased the number of live reproductive organs compared with dicamba or 2,4-D alone for both cultivars. Floral abortion on tomato plants was also reduced when ML or WP was applied before an herbicide treatment by 12 WAT. Although WP and ML did not provide complete protection against synthetic auxin herbicide injury, the concept of using film-forming barriers may be useful in mitigating some of the short-term effects of drift on plants.