Fifty-six accessions of white sapote (Casimiroa edulis Llave & Lex.) grown in situ in 11 municipalities in the state of Michoacán, Mexico, were characterized using 14 morphometric variables (six of fruit and eight of seed). There was a high cv for fruit weight (0.50), the number of developed seeds (NDS) (0.48), and total seed weight (0.45). Principal component analysis (PCA) showed that the main differences among the C. edulis accessions were fruit weight, seed projected area, Feret diameter (FD), the length of polar and equatorial axes of the fruit, the number of undeveloped seeds (NUS), the NDS, hardness of the skin (HS), and total soluble solids content of the fruits. Three groups of accessions were determined by cluster analysis (CA). The first group was made up of 53 accessions with intermediate values of fruit size and seed size. The second group, comprising two accessions, had the lowest values of fruit size. The third group showed an outstanding individual with the highest values for fruit size/weight, seed weight, and total soluble solids. Through an in-depth examination of the genotypes of the first group, four genotypes were identified for their positive characteristics. The results indicate an extremely high variability in the fruit and seed characteristics produced by different trees/genotypes of white sapote in Mexico. Hence, an initial, preliminary individuation/selection of five genotypes could be considered for the development of new cultivars for establishing white sapote orchards in Mexico.