Commercialization of crops tolerant to application of 2, 4-dichlorophenoxyacetic acid (2,4-D) and dicamba is a cause of major concern for sweetpotato (Ipomoea batatas) producers regarding potential negative impacts due to herbicide drift or sprayer contamination events. A field study was initiated in 2016 and repeated in 2017 to assess impacts of reduced rates of combinations of glyphosate with 2,4-D or dicamba on sweetpotato growth and production. Reduced rates of 1/10x, 1/33x, 1/66x, and 1/100x of a 1x rate of glyphosate at 1 lb/acre plus 2,4-D choline at 0.94 lb/acre and glyphosate at 1 lb/acre plus diglycolamine salt of dicamba at 0.5 lb/acre were applied to ‘Beauregard’ sweetpotato at 10 or 30 days after transplanting. With respect to visual injury, in general glyphosate plus dicamba proved to be more injurious than glyphosate plus 2,4-D, especially within the lower rate range. In most cases injury was greater at the later application timing. In either case, typical hormonal herbicide symptomology was quite evident 35 days after application. With respect to U.S. No. 1 and total (U.S. No. 1, canner, and jumbo grade) sweetpotato yield, greatest negative impact was observed with herbicide application at the upper rate range, particularly the 1/10 and 1/33x rates, and at the later application timing regardless of herbicide applied.