Research on sapodilla (Manilkara zapota) has been very limited. A field study was conducted to determine the yield potential, fruit quality traits, leaf nutrient composition, and scion/rootstock compatibility of ‘Prolific’ sapodilla grafted onto 16 sapodilla rootstock seedlings. For this purpose, seedlings (maternal half-sibs) of cultivars Adelaide, Arcilago, Aruz, Blackwood, Blocksberg, Guilbe, Hanna, Jamaica-1, Larsen, Mendigo-1, Gallera, Morning Star, Russel, Prolific, Timothe, and Vasallo-1 were used as rootstock seedlings and evaluated during 7 years of production at Isabela, PR. Year showed a significant effect on the number of fruit per hectare, yield, individual fruit weight, fruit length and diameter, and total soluble solids. Rootstock seedlings had a significant effect on the number of fruit per hectare, yield, and individual fruit weight but had no effect on other fruit traits. The year × rootstock interaction was not significant for any of the variables measured in the study. Rootstock seedlings ‘Timothe’, ‘Vasallo-1’, ‘Larsen’, and ‘Aruz’ had the highest 7-year mean for number and the yield of fruit averaging 4479 fruit/ha and 1245 kg·ha−1, respectively. ‘Timothe’ and ‘Vasallo-1’ significantly out yielded the ‘Prolific’ rootstock seedling. The number of fruit per hectare and corresponding yield obtained in this study were very low probably as the result of wind exposure, the presence of the fungus Pestalotia causing floral necrosis, or both. Scion/rootstock incompatibility was not the cause of the low yield performance of grafted trees. The average individual weight of fruit was 282 g and ranged from 264 to 303 g. Averaged over rootstock seedlings, leaf tissue nutrient concentration did not vary greatly over time. Moreover, tissue nutrient concentration was similar before and after fertilization events.