Mulch is often applied in landscape planting beds for weed control, but little research has focused specifically on mulch and preemergence (PRE) herbicide combinations. The objectives of this research were to determine the efficacy of herbicide + mulch combinations and which factors significantly affected weed control, including herbicide formulation and posttreatment irrigation volumes. Additional objectives were to determine efficacy derived from mulch or herbicides used alone under herbicide + mulch combinations and to identify differences in the additive (herbicide + mulch combinations) or singular (herbicide or mulch) effects compared with the use of herbicides or mulch only. Large crabgrass (Digitaria sanguinalis), garden spurge (Euphorbia hirta), and eclipta (Eclipta prostrata) were used as bioassay species for prodiamine, dimethenamid-P + pendimethalin, and indaziflam efficacy, respectively. The experiment consisted of a factorial treatment arrangement of two herbicide formulations (granular or spray applied), three mulch types [hardwood chips (HWs), pine bark (PB), and pine straw (PS)], two mulch depths (1 and 2 inches), and three levels of one-time, posttreatment irrigation volumes (0.5, 1, and 2 inches). Three sets of controls were used: the first set included three mulch types applied at two depths receiving only 0.5-inch irrigation volume, the second set included only two herbicide formulations and three one-time irrigation volumes, whereas the last set received no treatment (no herbicide or mulch) and only 0.5-inch irrigation volume. High levels of large crabgrass and garden spurge control (88% to 100%) were observed with all herbicide + mulch combinations evaluated at mulch depths of 1 inch or greater. When comparing mulch types, the best eclipta control was achieved with hardwood at 2 inches depth. The spray formulation of indaziflam outperformed the granular formulation in most cases when used alone or in combination with mulch. Overall, the results showed that spray formulations of prodiamine and dimethenamid-P + pendimethalin were more effective than granular formulations when applied alone, whereas indaziflam was more effective as a spray formulation when used both alone and in combination with mulch. Increasing irrigation volume was not a significant factor for any of the herbicide + mulch combinations when evaluating overall weed control.