Nursery and greenhouse growers use a variety of practices known as best management practices (BMPs) to reduce sediment, nutrient, and water losses from production beds and to improve efficiency. Although these BMPs are almost universally recommended in guidance manuals, or required by regulation in limited instances, little information is available that links specific BMPs to the scientific literature that supports their use and quantifies their effectiveness. A previous survey identified the most widely used water management, runoff, and fertilizer-related BMPs by Virginia nursery and greenhouse operators. Applicable literature was reviewed herein and assessed for factors that influence the efficacy of selected BMPs and metrics of BMP effectiveness, such as reduced water use and fertilizers to reduce sediment, nitrogen (N), and phosphorus (P) loads in runoff. BMPs investigated included vegetative zones (VZs), irrigation management strategies, and controlled-release fertilizers (CRFs). Use of vegetative buffers decreased average runoff N 41%, P 67%, and total suspended solids 91%. Nitrogen, P, and sediment removal efficacy increased with vegetative buffer width. Changes in production practices increased water application efficiency >20% and decreased leachate or runoff volume >40%, reducing average N and P loss by 28% and 14%, respectively. By linking BMPs to scientific articles and reports, individual BMPs can be validated and are thus legitimized from the perspective of growers and environmental regulators. With current and impending water use and runoff regulations, validating the use and performance of these BMPs could lead to increased adoption, helping growers to receive credit for actions that have been or will be taken, thus minimizing water use, nutrient loss, and potential pollution from nursery and greenhouse production sites.