Field and greenhouse studies were conducted in 2001 and 2002 near Painter, VA, to determine the level of weed control and pepper (Capsicum annuum) tolerance to postemergence applications of the acetolactate synthase (ALS) inhibitors trifloxysulfuron, halosulfuron, sulfosulfuron, cloransulam, and tribenuron. Based on measurements of visual injury, heights, dry weights, and chlorophyll content of pepper, the safest ALS inhibitor to pepper was trifloxysulfuron followed by halosulfuron, cloransulam, sulfosulfuron, and tribenuron. In addition, trifloxysulfuron was the only herbicide that provided greater than 86% control of pigweed species (Amaranthus spp.) and carpetweed (Mollugo verticillata) in both years of the field study. Trifloxysulfuron was also the only herbicide evaluated that did not reduce pepper yield compared with the control in both years of the field study.