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The nature and magnitude of genotype × environment interactions will determine the extent of testing required (locations, years) to accurately evaluate a genotype's performance. Data from yearly T-AES muskmelon variety trials were analyzed to determine the level of variety (V) × year (Y), V × location (L), and V × Y × L interactions for yield and fruit size. Data analyzed were of nine hybrids grown at three commercial farms over two years. Fruits were harvested similar to grower practices, and were sorted into size classes (9 - 30) or culls. V × Y and V × L interactions for marketable yield and total yield were not significant. V × Y × L interaction was significant for marketable yield, but not for total yield. V × Y × L interactions were highly significant for percentage culls and percentage of fruit in each size class. V × L interactions were also significant for percentage of fruit in most size classes. Data indicate that specific location-year combinations differentially affect a genotype's fruit size, most likely due to weather, planting time, and stress factors. Multiple year and location testing of genotypes is therefore critical, particularly for evaluation of fruit size.