Roughstalk bluegrass (Poa trivialis L.) is a troublesome weed on golf courses, home lawns, and athletic fields from the Midwest to the mid-Atlantic states. Bispyribac-sodium and sulfosulfuron have recently been labeled for roughstalk bluegrass control, but their use needs to be refined. Our objective was to determine the most effective herbicide strategies for control of roughstalk bluegrass. Initial studies were conducted during 2005 in Illinois and Indiana and follow-up studies in 2006 in Indiana, Illinois, South Dakota (partial shade and full sun), and Wisconsin. Applications starting in the warmer temperatures of late May and June 2005 were more effective than those starting in mid-May. Bispyribac-sodium (a.i.) was applied at 74 or 114 g·ha−1 four times at 2-week intervals decreased roughstalk bluegrass cover to 1% and 0% 12 weeks after initial treatment (WAIT) in Illinois and Indiana in 2005, respectively, whereas sulfosulfuron (a.i.) at 13 or 27 g·ha−1 applied twice at 2-week intervals decreased cover to no less than 18%. In 2006, bispyribac-sodium was most effective in Indiana and Illinois decreasing cover to as low as 4%, whereas sulfosulfuron was most effective in South Dakota resulting in a decrease in cover to as low as 7%, and both herbicides performed similarly in Wisconsin. Three applications of sulfosulfuron (a.i.) at 27 g·ha−1 at 2-week intervals or four applications of bispyribac-sodium (a.i.) at 56 or 74 g·ha−1 at 2-week intervals were most effective for roughstalk bluegrass control.