Combinations ofvarious vegetable crop species grown in multiple-cropping sequences using microirrigation on a sandy soil were evaluated for production potential and changes in normal cultural management An initial fall-season fresh-market tomato crop was followed immediately by a winter-season crucifer crop (cauliflower, broccoli, or cabbage), which was followed by a spring-season cucurbit crop (cucumber, zucchini squash, or muskmelon). Studies were conducted over a 3-year period in southwestem Florida. Results showed that when cropping sequences were compared on a basis of a derived relative value index (RVI), the sequence of tomato-cauliflower-zucchini squash significantly outperformed other sequences. Several management concerns particular to the production system (crop residue removal and interference, plastic mulch deterioration and damage, and weed control) were identified and discussed. The potential savings when cropping sequences are compared to individual crop production resulted in net savings (dollar savings less additional production costs) that ranged from $565 to $1212/acre ($1396 to $2993/ha) and $614 to $1316/acre ($1516 to $3251/ha) for the 1986-87 and 1988-89 seasons, respectively.