This article examines the nutritional quality and human health benefits of melons, specifically, muskmelon or cantaloupe (Cucumis melo L. var. reticulatus Naud.) and honeydew melon (Cucumis melo L. var. inodorus Naud.) types. Melons are naturally low in fat and sodium, have no cholesterol, and provide many essential nutrients such as potassium, in addition to being a rich source of beta-carotene and vitamin C. Although melons are an excellent source of some nutrients, they are low in others, like vitamin E, folic acid, iron, and calcium. Since the U.S. diet is already high in fat and protein content, melons should be included in everyone's diet, along with five to eight servings per day of a variety of other fruit and vegetables, to ensure adequate nutrition, promote individual health, and reduce one's risk of cancer and certain other chronic diseases.