Five greenhouse and two Geld experiments were conducted to evaluate tissue culture-propagated (TC) raspberry (Rubus idaeus cv. Heritage) sensitivity to preemergent herbicides. Plant performance was measured by plant vigor, above-ground fresh weight, root development, and primocane number. Simazine and oryzalin caused significant injury to newly planted TC raspberry plants in greenhouse and field experiments. The severity of injury was generally linear with respect to herbicide rate, but no appreciable differences in injury were observed between the granular and spray applications. Napropamide wettable powder caused some foliar injury, but plants recovered within one growing season and growth was equal or superior to the hand-weeded controls. The granular formulation of napropamide produced similar results, but did not cause the initial foliar burn. Pre-plant dipping of roots into a slurry of activated carbon did not prevent simazine or oryzalin injury, but injury was reduced when herbicide applications were delayed. Simazine applied 4 weeks after planting was not Injurious, and oqzalin applied 2 or 4 weeks after planting caused some foliar injury, hut no reduction in plant fresh weight. Delayed treatments of napropamide increased foliar injury. Herbicide tolerance of tissue-cultured plantlets appeared to be less than that of conventionally propagated plants. Chemical names used: N,N-diethyl-2-(1-napthalenyloxy)propanamide (napropamide), 4-(dipropylamino)-3,5-dinitrobenzenesulfonamide (oryzalin), 6-chloro-N,N'diethyl-1,3,5-triazine-2,4-diamine (simazine).