Two separate experiments (one and two applications and dates of treatment) were conducted on plant growth regulator (PGR) injury and seedhead suppression of centipedegrass [Eremochloa ophiuroides (Munro) Hack.]. Mefluidide caused less injury to centipedegrass than either imazethapyr or flurprimidol + mefluidide. Mefluidide applied at 0.56 kg·ha-1 in each of two applications at 2-week intervals suppressed seedheads of centipedegrass for 10 weeks. A single 0.56-kg·ha-1 application of the mefluidide failed to suppress seedheads when applied any time from mid-June until late July. A single treatment with flurprimidol + mefluidide severely injured centipedegrass, and seedhead suppression was poor regardless of date of treatment. Centipedegrass was severely injured when flurprimidol + mefluidide was applied at 1.68 + 0.28 kg·ha-1 in each of two applications, but seedheads were suppressed for 10 weeks. Imazethapyr applied at 0.30 and followed by 0.15 kg·ha-1 suppressed seedheads 10 weeks after treatment in 1987 and 6 weeks after treatment in 1988 without reducing turf density. When this PGR was applied as a single treatment at 0.30 kg·ha-1, seedhead suppression was generally greater for 8 weeks when applied mid- to late July than mid- to late June. Chemical names used: N-[2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide (mefluidide); α -(1-methylethyl)- α -[4-(trifluoromethoxy)phenyl]-5-pyrimidinemethanol (flurprimidol); and (±)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-ethyl-3-pyridinecarboxlic acid (imazethapyr).