Achillea millefolium L. is one of the most important medicinal plants because of its diverse medicinal uses including anti-infective, spasmolytic, choleretic, carminative, and anti-inflammatory activities (Benedek et al., 2007; Naeini et al., 2009).
It is spread in many regions of Iran. Investigation about the phytochemical components of A. millefolium is important for determining therapeutic agents having potential pharmaceutical value (Farnsworth, 1966; Pandith, 2012).
The many accessions of Iranian A. millefolium are known to produce a wide variety of chemical compounds in the essential oils, with the most abundant components identified as chamazulene, germacrene D, sabinene, β-caryophyllene, p-cymene, bornyl acetate, camphene, β-pinene, 1,8-Cineole, camphor, ascaridole, linalool, α- and β-thujone, cis- and trans β-ocimene, myrcene, limonene, γ-terpinene, caryophyllene oxide, a-bisabolol, β-eudesmol, and α-phellandrene (Dehghan and Elmi, 2015; Ebrahimi et al., 2012; Gudaityte and Venskutonis, 2007; Judzentiene, 2016; Sevindik et al., 2016; Stevanovic et al., 2015). In Iran, most studies on A. millefolium have been focused on only a few accessions that are limited to a single geographical area (Afsharypuor et al., 1996; Jaimand et al., 2006; Maz et al., 2013; Mazandarani et al., 2007). Ebrahimi et al. (2012) studied essential oil variation among five Achillea millefolium ssp. elbursensis collected from different ecological regions in Iran. In their study, accessions of subspecies of elbursensis were examined. To the best of our knowledge, there is not a comprehensive study on essential oil components of the plant in Iran.
The objective of this study was to expand the information on the chemical variations in essential oil of A. millefolium accessions from different regions in Iran.
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