Combining herbicides and fungicides can improve production efficiency; however, there is little information on the effect of these mixtures on weed control and processing tomato crop response. Six field trials were conducted from 2002 to 2004 in Ontario to study the effect of rimsulfuron and thifensulfuron applied alone or in combination with metribuzin and with or without chlorothalonil or copper fungicides on processing tomato. There was no visual injury or reduction in marketable yield of processing tomato with rimsulfuron or thifensulfuron alone or when tank-mixed with chlorothalonil or copper hydroxide. Rimsulfuron, thifensulfuron, rimsulfuron plus metribuzin, and thifensulfuron plus metribuzin could be tank-mixed with chlorothalonil without a reduction in weed control. However, efficacy of rimsulfuron and thifensulfuron were reduced when tank-mixed with copper hydroxide. The reduction in weed control incited by adding copper hydroxide was overcome with a low rate (150 g·ha–1 a.i.) of metribuzin for thifensulfuron but not rimsulfuron. Application of rimsulfuron and thifensulfuron alone or with low rates of metribuzin and chlorothalonil could provide tomato growers with a single-pass treatment for the control of troublesome weeds and diseases.