Effects of Tergitol-TMN-6 surfactant on blossom thinning (fruit set), fruit quality, and yield were studied in different cultivars of peach (Prunus persica [L.] Batsch) during 2003 to 2005, and in one cultivar of nectarine Prunus persica [L.] in one orchard and one cultivar of plum (Prunus domestica [L.]) in two orchards in 2004. In addition to Tergitol-TMN-6, effects of Crocker's fish oil (CFO) alone in three peach cultivars or in combination with lime sulfur in a nectarine cultivar were studied on fruit set, quality, and yield. Tergitol-TMN-6 at 5 mL·L–1 or higher rates, applied at about 75% to 85% bloom, reduced fruit set without russeting peach fruit. Peach fruit size was often increased by Tergitol-TMN-6 treatment. Applications of Tergitol at 20 mL·L–1 or 30 mL·L–1 excessively thinned peaches. Tergitol-TMN-6 at all rates burned foliage, but the symptoms disappeared after a few weeks without any adverse effects on tree productivity. Tergitol-TMN-6 at 7.5 mL·L–1 or 10 mL·L–1, applied either once at about 80% to 85% bloom or twice at 35% bloom and again at 80% to 85% bloom, reduced fruit set without any fruit russeting in nectarine. Tergitol-TMN-6 at 7.5 mL·L–1 to 12.5 mL·L–1 reduced fruit set in `Empress' plum. CFO at 30 mL·L–1 was effective in blossom thinning of some peach cultivars. A combination of lime sulfur and CFO was not effective in blossom thinning of nectarine. Considering results from several orchards in different locations in the Pacific Northwest over 3 years, Tergitol-TMN-6 is an excellent blossom thinner for peach, nectarine, and plum at rates of 7.5 to 12.5 mL·L–1, sprayed at a spray volume of 1870.8 L·ha–1 when about 75% to 85% blooms are open.