Prohexadione-Ca (ProCa) is a relatively new plant growth regulator (PGR) that inhibits internode length in rice, small grains, and fruit trees. However, little is known about its efficacy and potential phytotoxicity on floriculture crops and how it compares to other commercially available PGR chemicals. The effects of two foliar spray applications (2 weeks apart) of ProCa (500, 1000, or 2000 ppm), paclobutrazol (30 ppm), or a tank mix of daminozide plus chlormequat (2500 and 1000 ppm, respectively) were quantified on Dianthus barbatus L. `Interspecific Dynasty Red', Ageratina altissima R. King & H. Robinson (Eupatorium rugosum) `Chocolate', Lilium longiflorum Thunb. `Fangio', and Buddleia davidii Franch. `Mixed.' All plants were forced in a glass-glazed greenhouse with a constant temperature setpoint of 20 °C under a 16-h photoperiod. Two weeks after the second spray application of ProCa at 500, 1000, or 2000 ppm, plant height of Dianthus and Lilium was shorter than control plants by 56%, 60%, and 65% and by 6%, 26%, and 28%, respectively. However, ProCa bleached and reduced the size of Dianthus flowers. ProCa at 2000 ppm and daminozide plus chlormequat were effective at controlling the height of Eupatorium (64% and 53% reduction, respectively); however, leaves of Eupatorium were discolored and showed symptoms of phytotoxicity 1 week after the first ProCa application. Only daminozide plus chlormequat were effective on Buddleia. ProCa is an effective PGR for most of the crops we tested; however, its discoloration of red flowers and foliage may limit its application for commercial use.