This paper summarizes the management framework of a multi-state, multi-institutional partnership delivering a targeted train-the-trainer program. The program provided Good Agricultural Practices (GAPs) and Good Manufacturing Practices (GMPs)-based training to southeastern U.S. fresh fruit and vegetable (produce) growers and packers. Twelve southern U.S. states cooperated in this project: Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, and Virginia. The 2000–04 work was funded by United States Department of Agriculture – Cooperative State Research, Education, and Extension Service (USDA–CSREES) National Food Safety Initiative grants. This project developed materials, pilot tested them, refined them for use by a regional group of specialized agents, assisted the agents in delivering the new programming and evaluated the results.