Previous research has shown the effectiveness of prodiamine (FactorÆ)as a preemergent herbicide. The objective of this experiment was to evaluate the efficacy and phytotoxicity of prodiamine applied to several woody ornamental and weed species. Phytotoxicity effects were evaluated on eight ornamental species: azalea (Rhododendron indicum `Mrs. G.G. Gerbing'), dwarf yaupon (Ilex vomitoria `Nana'), dwarf mondograss (Ophiopogon japonicus `Nana'), ixora (Ixora coccinea), lantana (Lantana camara `New Gold'), Southern live oak (Quercus virginiana), weeping fig (Ficus benjamina), and daylily (Hemerocallis fulva). Preemergent herbicide treatments (control-nontreated, 2 lbs aia Factor®, and 4 lbs aia Factor®) were applied to ornamentals twice during the experiment at twelve week intervals. There was a reduction in top dry weight for azalea and dwarf mondograss for both 2 and 4 lbs aia treatments. No significant growth reductions were measured for daylily, dwarf yaupon, ixora, lantana, live oak, and weeping fig. The efficacy experiment consisted of four weed species: barnyardgrass (Echinochloa crusgali), crabgrass (Digitaria sanguinalis), coffeeweed (Sesbania exaltata), and pigweed (Amaranthus retroflexus) and five preemergence herbicide treatments (control-nontreated, control-Rout® at 100 lbs/A, Factor® 1 lb aia, Factor® 2 lbs aia, and a tank mixture of Factor® 1 lb aia plus Gallery® 1 lb aia) applied to bark-filled containers. Twenty-five weed seeds of each species were broadcast over each container following herbicide applications. The high rate of Factor®, Rout®, and the combination of Factor®+Gallery® significantly reduced weed dry weight compared to the control. All preemergence herbicides significantly reduced weed counts and height in a similar manner.