Virus infections and genetic mutations have been implicated in the decline of sweetpotato yield and quality. Virus-tested mericlones were derived from 12 infected clones of `Beauregard' sweetpotato by meristem-tip culture. Field studies were conducted to evaluate yield differences between the virus-tested and the virus-infected plants of each respective clone. After a 90-day growing period, the storage roots were harvested, weighed, and analyzed with a colorimeter to gauge color of skin and flesh. Yield was 7% to 130% greater in virus-tested mericlones compared to their respective virus-infected clone. Data also show these 12 virus-tested mericlones vary in yield by up to 118%. This suggests genetic differences between clones greatly affect yield. The virus-tested mericlones also show a more desirable darker-red hue for skin and flesh than the virus-infected clones. The incorporation of virus-tested material into foundation seed programs could potentially increase yield and quality with little added expense to growers, thereby netting a higher return on their crop.