Since 1980, farmers from western Mexico have cultivated melon cantaloupe; however, during the past few years, they have seen the better advantages of honeydew melon. Some of them represent a good alternative to farmers because chemical products and labor costs are reduced, and because they are tolerant to several diseases. The purpose of this experiment was to evaluate 15 new hybrids of honeydew melon in western Mexico. The hybrids evaluated were: Dey Break, Hmx 4596, Hmx 4595, Hmx 4607, Sunex 7051, Rocio, creme de menthe, Silver world, Emerald sweet, Sme 5303, Sme 5302, Santa Fé, PSR 10994, and PSR 8994, Honey Brew was test. Fifteen -day-old plants were transplanted by hand. Treatments were replicated four times in a randomized complete-block design. Beds 1.2 m wide and 7.0 m long were prepared, 1.5 m between beds, distance plant-plant 0.5 m (plant density ≈13,332 plant/ha). Results show that yield of SME 5302, SME 5303, HMX 4596, Rocío, Dey Break, PSR 8994, Sunex 7051, and HMX 4607 had a yield higher of 50 t/ha, Emerad sweet had more number fruit (59 per 10 plants), whereas SME 5303, SME 5302 and Silver world had higher fruit weight (>1.719 gr). We suggest the evaluation of these hybrids in other regions to know the adaptation to different conditions and to select the best in commercial quality and production.