Rooted cuttings of 22 different Euphorbia pulcherrima Willd. ex Klotzsch cultivars were grown in root substrate inoculated with 0, 5000,15,000, and 30,000 oospores of Pyuthium ultimum Trow per 10-cm containers. The root substrate was a mixture of 50% peat, 30% perlite, and 20% soil, adjusted to a pH 5.5. Plants were grown in a greenhouse with a temperature range of 15-32 °C, and were fertilized daily with 200 ppm N (Excel 15-5-15, Scotts Co. Marietta, Ga). After 8 weeks, roots were rated for disease incidence and root fresh and dry weights were determined. The data were analyzed using ANOVA with six blocks in a 22 × 4 factorial design, linear regression, and cluster analysis. Significant differences among the responses of the cultivars were found. The slopes of the regression equations, using the log10 of the inoculum level for the X axis, were more positive for disease incidence and more negative for fresh and dry root weights in the more susceptble cultivars. The cultivars were separated, by the cluster analysis, into three groups, less susceptible, moderately susceptible, and highly susceptible. Cultivars Marblestar and Galaxy Red were representative of less susceptible, `Pepride' and `Jolly Red' were representative of moderately susceptible, and `Snowcap' and `Success' were representative of highly susceptible cultivars.