The benefit of applying an antitranspirant for protection of cranberry (Vaccinium macrocarpon Ait.) vines exposed to desiccating conditions was evaluated at four different sites, two sites per year, for a period of 1 year each. Overall, plots receiving one fall application of an antitranspirant produced more berries and greater total fruit mass the following year than did nontreated plots. Overall dry leaf mass was not significantly affected. At one site, treated plots had more flowering uprights and more flowers per upright per unit of ground area than the nontreated plots. For cranberry growers who cannot maintain a winter flood, one fall application of pinolene (Vapor Gard) may offer some protection against winter injury. Further research is needed to document long-term yield effects as well as to clarify the role of the antitranspirant in protecting exposed vines and floral buds against adverse winter conditions. Chemical name used: di-1-p-menthene (pinolene).