Sweetpotato whitefly (Bemisia tabaci Gennadius) is one of the serious pests on cucurbits and causes injury by sucking sap and by the transmission of virus. In Western Mexico, melon and other vegetable crops have been subjected to losses as a results of whitefly feeding and whitefly-transmitted virus infection. Traditional control is based in the Metamidophos and Endosulfan applications (more than 10 times). Recently, Imidacloprid has been reported as new alternative to whitefly control. Thus, this study was conducted to determine the effect of Imidacloprid under different applications methods on sweetpotato whitefly populations and cantaloupe yield. Ten treatments were evaluated: 1) seed + basal stem, 2) seed + soil at 8 cm, 3) seed + soil (near to seed), 4) seed + soil (seedlings emergence), 5) seed only, 6) basal stem, 7) soil (plant emerged), 8) foliage, 9) Metamidophos and Endosulfan (regional application), and 10) control, without application. These were arranged in a randomized complete-block design with four replications. Each replication had four beds 7.5 m long. Number of whitefly adults was determined weekly on 24 plants selected at random for each treatment (two leaves/plant). At 22, 39, 57, and 73 days after showing, the whitefly nymphs/cm2 were also counted. Imidacloprid applied to foliage five times showed the best whitefly control during the entire crop season, reducing injury and increasing melon yield at 1346.7 cartons/ha, while Metamidophos and Endosulfan showed an intermediate effect (1073.6 cartons/ha).