Watermelon is the major fresh-market vegetable grown in Oklahoma, but growers have few labeled herbicides from which to choose. Grower surveys in Oklahoma have identified weed control as the major production problem facing watermelon producers. In 1995 and 1996, various mechanical and chemical weed control strategies have been explored. `Allsweet' watermelons were grown with various combinations of labeled and unlabeled herbicides, as well as mechanical control treatments. Treatments included bensulide, clomazone, DCPA, ethalfluralin, glyphosate, halosulfuron, napropamide, naptalam, paraquat, pendimethalin sethoxydim, and trifluralin. Certain chemicals were used in combination. Paraquat and glyphosate were used as wipe-on materials. Glyphosate and paraquat could not be applied until weeds were taller than the watermelon foliage, causing serious weed competition. In general, superior results were obtained from hand-weeded plots, trifluralin, and DCPA. Halosulfuron gave superior control of broadleaf weeds, but had a negligible effect on grasses. Napropamide gave good control of grasses and broadleaf weeds other than solanaceous weeds. No chemical, when used alone, gave satisfactory control throughout the growing season. Early cultivation, followed by chemical application at layby, appears to be one of the better treatments.