Polygalacturonase (PG) is the principal enzyme responsible for the softening of tomato during ripening. Transformation of tomatoes with antisense PG (asPG) results in significant delay in softening so that fruits with color and flavor can be harvested and shipped from the fields to distant markets. Safety evaluations of the genetically engineered tomato varieties were conducted from two perspectives: a) agricultural, and b) human food. Data were submitted to the appropriate agencies to obtain approvals for commercial production and to seek advisory opinion for the safety of food for human consumption. Calgene Fresh Inc. was created to develop human resources, physical facilities and logistic capabilities for year round supply of high quality branded produce. Vertical integration from seed production to direct consumer marketing is necessary to optimize the business endeavor.